Dioctyl Sodium Sulfosuccinate

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Deye-oc-til SO-dee-um Sul-fo-SUK-si-nate - Pronunciation guide

Brand Names

  • Dioctynate


Dioctyl sodium sulfosuccinate, or DSS, works as a stool softener or laxative by reducing the surface tension of the impaction and permitting water to penetrate and soften the fecal mass.  It increases intestinal secretions and intestinal motility, aiding in its action.


Dioctyl sodium sulfosuccinate is used to treat horses with fecal impaction and foals with meconium impaction.  The treatment varies with the location in the gastrointestinal tract and the severity of the impaction.

Dosage and Administration

Dioctyl Sodium Sulfosuccinate
Method Dosage
(click row for calculator)
Concentration Period Duration
Enema 4-6 oz1 5% Every 48 hours 2 times
Oral 8 oz2 5% Every 48 hours 2 times


  • 1Mix with 1 gallon of water.
  • 2Mix with 1 gallon of water or mineral oil.

Side Effects

Dioctyl sodium sulfosuccinate can cause diarrhea and abdominal pain.


Excess fluid accumulation or gastric reflux should be ruled out before oral administration of DSS because the horse may not be able to propel the fluid forward and may be accumulating excess fluid in the stomach or small intestine.

Because of the secretory effects that high doses can produce, hydration and electrolyte status should be carefully monitored and treated when necessary.

DSS is sold only to veterinarians, and only a licensed veterinarian should perform nasogastric tubing.

No information is found regarding use in competition horses.


DSS should not be administered at the same time as mineral oil because its effectiveness may be compromised.


Higher doses of dioctyl sodium sulfosuccinate can cause severe diarrhea and increase abdominal pain.


Dioctyl Sodium Sulfosuccinate Liquid Dioctyl Sodium Sulfosuccinate Liquid




About the Author

EquiMed Staff

EquiMed staff writers team up to provide articles that require periodic updates based on evolving methods of equine healthcare. Compendia articles, core healthcare topics and more are written and updated as a group effort. Our review process includes an important veterinarian review, helping to assure the content is consistent with the latest understanding from a medical professional.